Post-doctorant - H/F
L'entreprise
L’Inserm est le seul organisme public français entièrement dédié à la recherche biologique, médicale et en santé des populations. Il dispose de laboratoires de recherche sur l’ensemble du territoire, regroupés en 12 Délégations Régionales. Notre institut réunit 15 000 chercheurs, ingénieurs, techniciens et personnels administratifs, avec un objectif commun : améliorer la santé de tous par le progrès des connaissances sur le vivant et sur les maladies, l’innovation dans les traitements et la recherche en santé publique.
Rejoindre l’Inserm, c’est intégrer un institut engagé pour la parité et l’égalité professionnelle, la diversité et l’accompagnement de ses agents en situation de handicap, dès le recrutement et tout au long de la carrière. Afin de préserver le bien-être au travail, l’Inserm mène une politique active en matière de conditions de travail, reposant notamment sur un juste équilibre entre vie personnelle et vie professionnelle.
L'Inserm a reçu en 2016 le label européen HR Excellence in Research et s'est engagé à faire évoluer ses pratiques de recrutement et d'évaluation des chercheurs.
Le poste
U 970-PARCC
Decoding Chromatin Landscape to elucidate heart regeneration
We offer a highly supportive and collaborative research environment where ideas are openly discussed and interdisciplinary interactions are encouraged. The PARCC center provides access to state-of-the-art core facilities, including advanced imaging platforms (confocal, two-photon, and epifluorescence microscopy), histology and tissue analysis platforms, and flow cytometry facilities. The laboratory benefits from strong expertise in animal models, with access to facilities enabling the development of genetically engineered models, including CRISPR-based genome editing and transgenesis.
Main mission:
The successful candidate will contribute to projects investigating how endothelial and vascular cells coordinate responses to cardiac injury and drive regenerative processes. The work integrates experimental and computational approaches, including in vivo models (mouse and zebrafish), in vitro cardiac systems, with the opportunity to further develop the heart-on-chip platform, and functional assays. The position also involves bioinformatics analyses of multi-omics datasets, including single-nucleus RNA sequencing (snRNA-seq) and ATAC-seq, to characterize gene regulatory networks underlying cardiovascular repair. The postdoctoral researcher will have the opportunity to design and lead projects, actively contribute to methodological discussions, and develop innovative approaches to address fundamental questions in cardiovascular biology.
Activities main :
• Establish and perform models of myocardial injury in adult mice and apical resection in zebrafish to study cardiac regeneration and repair mechanisms.
• Conduct functional assessment of cardiac injury and regeneration using echocardiography, histology, and imaging approaches
• Perform molecular and cellular biology experiments, including cloning, gene expression analysis, and cellular characterization related to heart injury and regeneration.
• Carry out bioinformatics analyses and interpretation of multi-omics datasets using Python-based computational approaches.
• Analyze and integrate experimental and omics data to identify molecular pathways involved in cardiac injury response and tissue regeneration.
• Participate in experimental design, data interpretation, manuscript preparation, and presentation of scientific results.
Job specification(s) and environment :
• PARCC, a leading cardiovascular research center, where mouse models of myocardial injury, functional analyses, histology, and molecular and cellular biology experiments will be performed.
• Institut Imagine, which hosts advanced facilities dedicated to zebrafish models and imaging technologies, where apical resection experiments and cardiac regeneration studies in zebrafish will be carried out.
• The candidate will work in a multidisciplinary environment combining cardiovascular biology, animal models, omics technologies, and bioinformatics approaches, with access to state-of-the-art technological platforms and national and international collaborations.
Profil recherché
Expertise:
• PhD in cardiovascular biology, regenerative medicine, molecular biology, bioinformatics, or a related field
• Strong background in cardiac biology, tissue regeneration, or cardiovascular physiology
• Knowledge of omics approaches and data analysis methodologies is appreciated
• Understanding of molecular and cellular biology techniques and experimental design
Know-how :
• Experience in experimental and/or computational research
• Experience or strong interest in in vivo models, including mouse and zebrafish models
• Experience with in vitro cardiac systems is an asset
• Experience with histology, imaging, echocardiography, cloning, and molecular biology techniques is appreciated
Ability :
• Strong motivation for academic research and career development
• Ability to work independently while contributing actively to collaborative projects and team discussions
• Scientific curiosity, creativity, and critical thinking
• Good organizational and communication skills
• Interest in translating fundamental research findings into physiological and pathological contexts
Experience(s) required:
• Experience or strong interest in in vivo models, including mouse and zebrafish models
Diploma level and training:
Bac+8
Biginning:
17/08/2026
Duration:
48 Month
Working time:
Full time
Number of hours per week: 38h30
Annual leave 32 and Rtt 12
Teleworking activities:
1 to 2 days a week, subject to the line manager’s approval and after the first 6 months
Remuneration :
from 2985.82 € gross per month depending on professional experience in equivalent positions
Applicants should send their CV, letter of motivation.
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Document(s) :
Candidature facile