Postdoctoral Researcher - H/F
L'entreprise
L’Inserm est le seul organisme public français entièrement dédié à la recherche biologique, médicale et en santé des populations. Il dispose de laboratoires de recherche sur l’ensemble du territoire, regroupés en 12 Délégations Régionales. Notre institut réunit 15 000 chercheurs, ingénieurs, techniciens et personnels administratifs, avec un objectif commun : améliorer la santé de tous par le progrès des connaissances sur le vivant et sur les maladies, l’innovation dans les traitements et la recherche en santé publique.
Rejoindre l’Inserm, c’est intégrer un institut engagé pour la parité et l’égalité professionnelle, la diversité et l’accompagnement de ses agents en situation de handicap, dès le recrutement et tout au long de la carrière. Afin de préserver le bien-être au travail, l’Inserm mène une politique active en matière de conditions de travail, reposant notamment sur un juste équilibre entre vie personnelle et vie professionnelle.
L'Inserm a reçu en 2016 le label européen HR Excellence in Research et s'est engagé à faire évoluer ses pratiques de recrutement et d'évaluation des chercheurs.
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Inserm is the only French public research organization entirely dedicated to biological, medical, and population
health research. It operates research laboratories across the whole country, grouped into 12 Regional
Delegations. The institute brings together 15,000 researchers, engineers, technicians, and administrative staff, all
working toward a common goal: improving everyone’s health through advances in our understanding of living
systems and diseases, innovation in treatments, and public health research.
Joining Inserm means becoming part of an institute committed to gender equity and professional equality,
diversity, and the support of staff with disabilities—from recruitment through every stage of their career. To
preserve well-being at work, Inserm implements an active policy to ensure favourable working conditions, based
in particular on a fair balance between personal and professional life.
Inserm received the European HR Excellence in Research label in 2016 and is committed to improving its
recruitment and researcher evaluation practices.
Le poste
Paris Centre de Recherche Cardiovasculaire (U970)
The PARCC (Paris Cardiovascular Research Center, Inserm U970) brings together a critical mass of basic science researchers and clinicians who share a common vision and common objectives in the field of cardiovascular diseases. The PARCC is part of Université Paris Cité and its Institute of Cardiovascular Sciences. Team Bouatia-Naji is member of the iWiSH (interdisciplinary institute of women’s health).
Team Bouatia-Naji gathers clinicians, statistical and molecular geneticists, and cell biologist to improve knowledge about cardiovascular disease predominant in women. We study the genetic causes and their biological translation in fibromuscular dysplasia (FMD) which manifest typically in early to middle adulthood in women in the context of stroke, hypertension of myocardial
infarction due to SCAD. FMD is an abnormal narrowing or bulging (stenosis and aneurysms) in medium-sized arteries. Unlike atherosclerosis, FMD is not caused by plaque build-up or inflammation, and its biological mechanisms remain largely unknown. Progress has been accelerating since our genetic discoveries related to smooth muscle cell contraction function and the role of extracellular matrix biology. Modelling of recently discovered common and rare genetic variation involved in FMD risk will be key to fully understand its specific biology, and set the
stage for targeted therapeutics.
The postdoc position is part of a Leducq Network of Excellence (Align-FMD, see website). Partner Bouatia-Naji is leading the induced pluripotent stem cell-derived SMCs differentiation of genetic
variation associated with FMD, in loss-of-function, gain-of-function and variant-specific models.
Effects on SMCs and their ECM will be evaluated through functional endpoints, including migration, proliferation, adhesion, and ECM synthesis. Testing will be conducted in variant specific and gene specific models, utilizing genetic methods to alter candidate genes’ DNA sequence (CRISPR/Cas9) and/or expression levels, after nomination from the human genetic studies that is an important part of this project. The postdoc is expected to involved in this specific activity of this Leducq project, participate in an international context of research in interaction with members of the network.
Main activities
The postdoctoral researcher will work with iPS cell lines and their differentiated smooth muscle and endothelial cells, if applicable, ensuring their maintenance and daily follow-up.
The position also involves designing and refining cell-transfection approaches, exploring different methods to identify the most effective strategies for the team’s experiments. The researcher will routinely use core molecular biology techniques to support mechanistic studies related to vascular function. A central part of the work will also consist in characterizing cell populations through immunostaining and advanced imaging approaches, using optical, fluorescence, and confocal microscopy, as well as flow cytometry. Finally, the postdoctoral researcher will engage with supporting members of the lab involved in molecular and cell biology, including students, communicate about progress and propose analytical and research experiments. Leducq networks require high
level of communication skills in a large collaborative work environment.
Profil recherché
Desired Experience
• 3 to 5 years (PhD + postdoc, eventually) in vascular biology, including experience with iPSC
genetic modification and cell culture, and a strong background in molecular biology.
Degree Level and Education
• PhD in vascular biology or cell biology in the context of human disease.
Start Date July 1, 2026 at the earliest
Duration
18 months, Renewable
Work Hours
• Full-time
• 38.5 hours per week
• 32 days of annual leave and 13 days of RTT over a calendar year
Activities not suitable for remote work
Compensation
Monthly gross salary: €2,952.91 / depending on professional experience
in equivalent positions.
Contact
Please send your resume and cover letter to nabila.bouatia-naji@inserm.fr
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