PhD Position MSCA Doctoral Network LipidBRIGHT - H/F
L'entreprise
Lipids are of vital importance through integration in cell membranes, as energy source and in cellular signaling and function. As such, they also play decisive roles in cardiovascular disease, chronic kidney disease, cancer and chronic inflammatory disease. These diseases affect 33%, 60%, 10% and 33% of Europeans, and are responsible for >60% of global deaths. The European Doctoral Network LipidBRIGHT combines scientists, clinicians, companies and stakeholder organisations with expertise in these disease fields. By integrating expertise in lipids from the clinical, biomedical, technological and data science field across disease borders and by transferring complementary knowledge and technology, LipidBRIGHT aims to speed up innovations towards improved disease prevention, diagnosis, prognosis and therapy. LipidBRIGHT will train scientists in a close cooperation between academia, SMEs and industry partners. Key objectives are to provide: 1) Excellent scientific training on interdisciplinary level, covering lipid biochemistry and pathophysiology as well as clinical application 2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research 3) Exposure to both academic and non- academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative products and services. LipidBRIGHT builds on available patient cohorts, advanced technologies and established cooperations and strives to synergistically improve structural training on European level. LipidBRIGHT will nurture the development of young, broadly-trained scientists able to successfully bridge clinical with basic research as well as academia and industry, which is a cornerstone in effectively combatting complex diseases as cardiovascular disease, chronic kidney disease, cancer and chronic inflammatory disease. For more information: https://www.cordis.europa.eu/project/id/101225380
Unité mixte de recherche U1116 DCAC
9 Avenue de la Forêt de Haye, Campus Brabois-Santé, Bâtiment D
VANDOEUVRE-LES-NANCY 54505
Directeur: Prof. Magnus BÄCK
Le poste
Main activities:
Cardiovascular disease (CVD) is the leading cause of death in Europe and a major public health concern, affecting over 49 million people and costing the EU approximately €200 billion annually. Despite advances in treatment, lifestyle-related challenges continue to complicate CVD management. Chronic inflammation, particularly in atherosclerotic cardiovascular disease (ASCVD), is a key issue. It arises from ineffective resolution of inflammation, leading to plaque instability and potentially severe events such as heart attacks and strokes. While lifestyle interventions, including a healthy diet and regular physical activity, can help control inflammation, elevated blood lipid levels remain a significant risk factor. Lipid-lowering therapies are effective, yet residual inflammation continues to pose a threat. Consequently, dietary strategies aimed at regulating lipids may complement existing preventive measures and provide new opportunities to tackle chronic inflammation and reduce cardiovascular risk.
The PhD student will investigate the mechanisms underlying the resolution of chronic lipid-driven vascular inflammation using in vivo and in vitro approaches. The project aims to identify and validate functional, molecular and immune-metabolic targets capable of diagnosing, preventing, and treating the transition from health to CVD by promoting effective inflammation resolution.
Profil recherché
Researcher profiles: first stage researcher (PHD Candidate)
Research fields: biological sciences, medical sciences, pharmacological sciences, other: physiology, life sciences or a related field
Specific requirements or constraints:
MSc degree in Physiology, Life Sciences, Medical/Pharmaceutical Sciences, or a related field
Animal experimentation qualification
Strong background in Molecular Biology and Histology
Experience in Biochemistry, Mass Spectrometry, and Flow Cytometry
Experience in Proteomics and Metabolomics is highly advantageous
Eligibility criteria :
Are at the date of recruitment doctoral candidates (DCs) (must NOT have a doctoral degree)
DCs can be of any nationality
Must comply with the following mobility rule: not have resided in the country of the recruiting beneficiary for more than 12 months in the 36 months immediately before the recruitment date (and not have carried out their main activity (work, studies, etc.) in that country) — unless as part of a procedure for obtaining refugee status under the Geneva Convention. For beneficiaries that are international European interest organisations or international organisations: not have spent with the beneficiary more than 12 months in the 3 years immediately before the recruitment date.
Skills/qualifications:
Strong organizational skills, dedication and proactiveness
Willingness to participate in networking activities
Required experience: 0 to 2 years
Required education level or diploma: MSc degree
Required languages:
Fluency in written and spoken English
Knowledge of French is appreciated
Type: Doctoral contract : MARIE SKŁODOWSKA-CURIE ACTIONS (MSCA)
Duration: 36 months
Salary:
The doctoral candidate (DC) will receive a 36-month scholarship intended to cover living expenses. The amount of the scholarship is based on a monthly living allowance, adjusted through a country correction coefficient reflecting the cost of living in the host country. The final amount will be determined based on the candidate’s family situation, in accordance with MSCA rules. All training activities will be fully covered by the network through the Horizon Europe MSCA-DN grant, including travel and accommodation costs for annual meetings and other network-organised events. DCs will have access to a dedicated workspace and research facilities. Costs related to consumables and the execution of the research project will be covered by the host institutions
Envisaged start date: 1st September 2026
Deadline for application: 30 april 2026
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