Postdoctoral Researcher - H/F
L'entreprise
Inserm is the only French public organisation entirely dedicated to biological, medical and population health research. It has research laboratories throughout France, grouped into 12 Regional Delegations. Our institute brings together 15,000 researchers, engineers, technicians and administrative staff with a common goal: to improve everyone's health through advances in knowledge about living organisms and diseases, innovation in treatments and public health research.
Joining Inserm means joining an institute committed to gender parity and professional equality, diversity and support for its employees with disabilities, from recruitment and throughout their careers. In order to promote well-being at work, Inserm pursues an active policy on working conditions, based in particular on a fair balance between personal and professional life.
In 2016, Inserm was awarded the European HR Excellence in Research label and is committed to developing its recruitment and evaluation practices for researchers.
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The Paris Cardiovascular Research Centre (PARCC, France, https://parcc.inserm.fr/) conducts cutting-edge research encompassing clinical, translational and fundamental sciences in the cardiovascular field. PARCC's strategic research areas are structured around three priorities:
Gene and molecular signalling;
Immunity and metabolism
Predictive models and multidimensional approaches.
For each strategic area, PARCC develops a continuum between fundamental research, innovative development, translational research and patient benefit. These strategic priorities are developed in four main pathological contexts, targeting multi-organ diseases:
1/ macro- and microvascular pathologies associated with metabolic diseases,
2/ heart failure and sudden cardiac death,
3/ endocrine and resistant hypertension,
4/ renal hypertension pathologies and transplantation.
Le poste
Main mission:
The successful candidate will work on an ANR-funded project aimed at studying the role of macrophages in cardiac fibrosis using single-cell and spatial transcriptomics methods.
Main activities:
- Animal models of cardiovascular diseases (surgery)
- Management of transgenic mouse lines
- Conducting and analysing single-cell and spatial transcriptomics experiments
- Presenting results at international conferences
- Preparing figures for scientific publications
- Writing scientific publications (in English)
Specific features and environment of the position:
Emerging Inserm CPJ team within the Paris Centre for Cardiovascular Research-Inserm U970, team of approximately 5 to 8 people.
International team, English is the working language for both spoken and written communication.
Profil recherché
Knowledge:
- Cell biology
- Molecular biology
- Bioinformatics
- Cardiac pathophysiology
- Immunology, macrophage study models
- Cardio-immunology
- Fluent spoken/written scientific English
Hard Skills:
- Extensive experience in animal experimentation
- Extensive experience in animal surgery for cardiovascular pathology models
- Extensive experience in managing transgenic mouse lines
- Experience in preparing samples and single-cell RNA-seq libraries
- Extensive experience in single-cell RNA-seq analysis and spatial transcriptomics: analysis of multi-omics single-cell RNA-seq data and spatial transcriptomics with R or Python bioinformatics
- packages, data integration, data mining, etc.
- Extensive experience in flow cytometry
Soft Skills:
- Scientific rigour and organisation
- Autonomy
- Ability to work in a team
Desired experience:
2 to 4 years post-doctorate
Level of qualification and training
Bac +8
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Document(s) :
Candidature facile