Main Activities

·         Design, conduct and analyse in vivo studies in mouse models addressing NLRP3 inflammasome function and its physiological consequences

·         Perform pharmacological modulation experiments (NLRP3 inhibitors, acute and chronic dosing paradigms, dose-response designs)

·         Carry out multidimensional phenotyping of mouse models, including behavioural, metabolic and functional readouts

·         Investigate intracellular and inflammatory signalling pathways using Western blot, RT-qPCR, tissue dissection and protein/nucleic acid extraction

·         Lead quantitative analysis, statistical treatment and interpretation of experimental data

·         Prepare figures, manuscripts and oral presentations; contribute to publication of results as first author

Associated Activities

·         Contribute to the preparation of regulatory documents for animal experimentation (APAFIS procedures, project applications)

·         Co-supervise Master's and PhD students on experimental workflows and data analysis

·         Develop, standardise and document laboratory protocols; contribute to onboarding of new lab members

·         Participate in lab meetings, institute seminars and international conferences

·         Apply for competitive postdoctoral fellowships (EMBO, MSCA, FRM) with the support of the host team

·         Contribute to collaborative projects within the institute and with external partners

Specific Requirements or Constraints

·         Work with laboratory animals (mice), including handling, dosing, surgery and tissue collection; valid training for animal experimentation required (equivalent to French levels applicable to design and execution of procedures)

·         Occasional work outside standard hours, including weekends, imposed by experimental schedules and animal monitoring

·         Work in a BSL-2 environment and compliance with institutional hygiene, safety and ethical regulations

·         Position based at IGBMC, Illkirch; travel for conferences and collaborative visits

·         Working language English; French not required but recommended for daily life

Skills/Qualifications

·         PhD in neurosciences, physiology, pharmacology, immunology or a related biomedical field

·         Documented experience in preclinical in vivo rodent models, including experimental design and execution

·         Certified training in animal experimentation (functions covering design, execution and care)

·         Proficiency in molecular and biochemical techniques: Western blot, RT-qPCR, tissue dissection, protein and nucleic acid extraction, analysis of inflammatory and intracellular signalling pathways

·         Experience in pharmacological approaches, including inflammasome-targeting compounds

·         Advanced quantitative and statistical skills (GraphPad Prism, R, SPSS or equivalent)

·         Track record of first-author peer-reviewed publications

·         Experience in supervising junior researchers and in protocol standardisation

·         Autonomy, rigour, strong motivation and ability to work in a multidisciplinary collaborative environment

Required Languages

·         Working language English; French not required but recommended for daily life